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LT-HSCs obtained from the Gpx4 f/f mice or Gpx4 / mice (CD45.2) together with BM cells obtained from competitor mice (CD45.1) were transplanted into recipient mice (CD45.1.2), whose hematopoietic system was destroyed by a lethal dose of X-ray irradiation (Fig

[DOI] [PubMed] [Google Scholar] 61.Ravaglia S, Corso A, Piccolo G, et al

Revista de Bioqumica Nutricional: investigacin sobre el papel del glutatin en la defensa antioxidante celular y la funcin mitocondrial

Withaferin A (WA) has been found to not only inhibit the activity of GPX4 in neuroblastoma but also activate heme oxygenase-1 to increase intracellular Fe 3+ concentration, thereby inducing ferroptosis in neuroblastoma [136]