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Overall, our results indicated that during high fat feeding, PGC-1 adversely influences the ability of the liver to overcome APAP toxicity by orchestrating different metabolic pathways that finally lead to fatal outcome

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Thus, LDIR can affect gene transcription and expression, and can result in cell structure and functional changes that involve cell growth, proliferation and differentiation

[4] The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions