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The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice (Huang et al., 1997)

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Addressing these questions will not only improve our understanding of serotonin-driven tumor progression but also facilitate therapeutic targeting of the TGM2-GPX4 serotonylation axis in gastrointestinal cancer patients

Activity of the cystine-glutamate antiporter SLC7A11 modulates intracellular redox, cell death, and type 2 signature protein expression