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The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm, which can be fatal

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Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]