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Pachymic acid (PA), a triterpenoid compound isolated from Poria cocos , has been shown to ameliorate renal injury in a mouse model of renal I/R, potentially by inhibiting renal ferroptosis through the upregulation of the NRF2/HO-1 axis ( O -methyltransferase (COMT), has long been used as an adjunctive treatment for Parkinsons disease

Animal studies showed that deacetylation of APAP by the liver enzyme N-deacetylase yields a minor metabolite p -aminophenol [49]

In addition, selenoprotein expression could be affected by macrophage polarization state, as proposed for murine cells [48]