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Integrins represent a fundamental class of mechanotransducers that facilitate bidirectional mechanical communication across cell-ECM and cell-cell interfaces via sophisticated force-sensing mechanisms[136]

Compared to passive targeting, active targeting allows for more localized drug release, minimizing off-target effects on healthy tissues and improving overall therapeutic efficacy

Among them, 153 cycles involved patients who received an oral dose of 3,000 mg L-carnitine per day for a minimum duration of 30 days until the oocyte retrieval day in subsequent cycles

Other pathways known to influence aging and lipid biology and/or nutrient sensing include dietary restriction mechanisms including intermittent fasting paradigms