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Altered mTOR signaling in senescent retinal pigment epithelium

As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

Nude mouse transplantation tumor model experiments showed that the combined use of DSF and sorafenib showed a synergistic tumor growth inhibition effect, indicating that the combined use of copper and anti-tumor drugs has a synergistic promoting effect on ferroptosis of HCC cells (160)