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Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

Immunohistochemistry When mice reached end point, tissue was collected and stored in paraformaldehyde at 4C

Its also known to decrease because of infection and chronic disease

Drug treatment of PD motor symptoms is centred around pharmacological dopamine substitution with levodopa still being considered the most efficacious agent, while dopamine agonists (DA agonists) have overall smaller effect size and greater risk of troublesome adversity including daytime sleepiness and impulse dyscontrol [6,7,8,9]