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The BBB consists of endothelial cells tightly joined by tight junctions, supported by astrocytic end-feet and pericytes, which collectively regulate the movement of ions, nutrients, and metabolic waste across the barrier while preventing the entry of pathogens, toxins, and potentially harmful immune cells (Abbott et al., 2010)

In this review, we summarize recent knowledge on Treg biology, translational applications of various Tregs products in the setting of GvHD and future endeavours in the field

However, 22%25% of patients are recurrent after resection in 10 years, and 50%70% are recurrent after transplantation (Vibert et al., 2020)

In order to focus sharply, three physiological responses, known as the triad of accommodation, are produced by a change in pupil size, a change in shape and position of the lens, and ocular convergence