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Lightening Dark Skin Above the Upper Lip Dark skin on the upper lip may be caused by excess melanin in the skin, sun exposure, hormonal changes, genetics/family history, certain medications, or thyroid disease

J Neurosci 27:65526562

The protective effect of Nigella sativa seeds against monosodium glutamate-induced hepatic dysfunction in rats

The permeability of the BBB is increased, facilitating the infiltration of leukocytes into the brain parenchyma to clear the substantial debris generated by cellular death [17]