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[,] Although one in three PBC patients who are treated with UDCA have no response to therapy, UDCA is still considered the first therapeutic choice for PBC

Twenty-four SpragueDawley rats (male, 8 weeks old) were randomly assigned to four groups ( n = 6): the AAV-NC group, IVDD + AAV-NC group, IVDD + AAV-MAPL group, and IVDD + AAV-shMAPL group

Acetaminophen inhibits the synthesis of prostaglandin (PG) E2, PGF2, and thromboxane B2 by lipopolysaccharide (LPS)-stimulated microglia, yet has no effect on the levels of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and NO [19,20]

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