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Accessed August 27, 2025

At a Glance When treating pernicious anemia, initial "loading" B12 injections are given frequently to rapidly refill dangerously empty stores and prevent nerve damage

Supporting this hypothesis, studies have demonstrated that in individuals with increased intestinal permeability, opioid peptides derived from gluten and casein can enter systemic circulation and potentially enhance opioid activity in the brain (Cass et al