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The STEP 4 trial [2] specifically examined weight maintenance after initial weight loss, showing that continued semaglutide treatment maintained weight loss, while participants switched to placebo regained an average of 6.9% of their body weight over 48 weeks (Rubino et al., JAMA, 2021)

To enable the selective release of essential drugs inside tumors, chitosan (CTS) coupled with biotin, a pH-sensitive additive, is attached to MSNs (158)