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Regarding folic acid, the upper assay limit of 45 nmol/L also hindered to assess whether plasma levels were extremely elevated

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

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If therapy is recommended, a personalized plan is developed and monitored regularly to ensure dosing remains appropriate and aligned with long-term health goals