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321 Recognition-memory impairment in an AD mouse model (5xFAD) can be accelerated by high-fat obesogenic diet by increasing blood levels of the metabolite N-acetylneuraminic acid (NANA), which results in systemic immune exhaustion

GSK3a/b is first inactivated by Akt-induced phosphorylation, which then causes dephosphorylation and activation of glycogen synthase [408]

Interestingly, polymorphisms in genes encoding acetaminophen-metabolizing enzymes might be responsible for dramatic ethnic and racial differences in APAP metabolism and toxicity [109113]