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Liao et al., 2021

Note that forskolin and rolipram strongly activates the synaptic cAMP-dependent pathways, while picrotoxin induces high-frequency firing, inducing LTP similar to that observed using electrophysiological stimulation

Combining the two in a single research protocol gives dual-pathway coverage of the regenerative cascade angiogenesis + cell-migration which is closer to the in-vivo process than studying either pathway in isolation