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Therefore, it is possible that the erythrocyte index may not reflect the brain index, but could reflect the uptake of DHA by other peripheral tissue that acquire DHA through non-Mfsd2a pathways, including uptake of free FA through diffusion, and the receptor-mediated uptake of lipoproteins

Other models use a co-culture of astrocytes, pericytes, neural stem cells and human induced pluripotent stem cell-derived BBB endothelial cells to improve BBB integrity [116]