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Rhein, one of the anthraquinone ingredients in the root of rhubarb, inhibits the phosphorylation of PI3K/AKT/FOXO3a, resulting in sustained high levels of Bim expression, which ultimately induces caspase cleavage and apoptosis [163]

(2009) demonstrated that anodal tDCS stimulation of the left dorsolateral prefrontal cortex (DLPFC) and temporal cortex improved visual recognition memory in Alzheimers disease (AD) patients