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10.1038/s43018-020-00126-z 121 StevensJ

For example, innate immune cell activation constipates specific catabolic transitions within the mitochondrial tricarboxylic acid cycle (TCA) resulting in accumulation of upstream substrates including citrate and succinate

However, most studies tend to focus on a single resistance mechanism, which may not capture the complexity of resistance in these populations or account for the interplay between multiple mechanisms [332]