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Evidence supports: Low glycemic index/glycemic load eating pattern: Reduces insulin and IGF-1 signalling, and supports healthy weight, which reduces aromatase-driven estrogen production Increased intake of cruciferous vegetables: Provide DIM (diindolylmethane) precursors that support Phase I/II estrogen metabolism Omega-3 fatty acids: EPA/DHA reduce pro-inflammatory prostaglandin production (PGE2), relevant to heavy bleeding Reduced alcohol: Alcohol raises estradiol levels and impairs hepatic estrogen clearance Food sensitivity identification: Chronic dietary-driven intestinal inflammation can contribute to systemic inflammatory load

Lysosomal proteolysis is a multistep lysosome-dependent degradation process whereby cytoplasmic constituents (e.g., protein aggregates, damaged organelles) are degraded through posttranslational modification (e.g., ubiquitin-dependent or chaperone-mediated mechanisms) [22]

In addition, the GPx defends against oxidants that cause neuronal and protein damage, which reduce H 2 O 2 and lipid peroxide to water and alcohol, respectively

With the data from the GLY feeding study, the baseline value for each animal was included in the model as a covariate to account for any differences between the groups that may exist