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The hydroxyl groups in quercetins structure can donate electrons to neutralize ROS like superoxide radicals and hydroxyl radicals

FIGURE 7 In summary, the antioxidant stress of GPX8 is not only related to the oxidative folding of endoplasmic reticulum proteins, but also may play a vital role in regulating endoplasmic reticulum Ca 2+

In addition, lactate alone or combined with tumor-derived colony-stimulating factor-2 (CSF2) induces macrophage polarization towards tumor-associated macrophages M2-like macrophages, which are more supportive of tumor progression compared with immune surveillance polarization (M1) [128,131]

ML: Conceptualization, Data curation, Investigation, Writing review & editing