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npj Precis

Acta Psychiatr Scand 2019;139:42033

The 3 prominent demethylases are the TETs, which are expressed in the brain, respectively, as Tet1 [39], Tet2, and Tet3 [51]

Circadian disruption in beta-Bmal1(-/-) mice and arrhythmic Clock 19 mice decrease the Nrf2 expression and subsequently impair the antioxidant defense system, contributing to increased ROS accumulation, oxidative damage and mitochondrial uncoupling