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10.1096/fj.02-0078fje 63

For all ventilated ARDS patients with mixed injurious causes, low tidal volume ventilation (normalized to predicted body weight) has been recommended to reduce ICU mortality [112]

In addition, (iv) the isocitrate dehydrogenases IDH1 and IDH2, which are located in the cytosol and mitochondria, respectively, are involved in NADPH production, and (v) glutamine metabolism is involved in NADPH generation through the glutamate dehydrogenases GDH1 and GDH2 in mitochondria