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AMPK activation leads to phosphorylation of ACC1 at Ser79 and ACC2 at Ser212, thereby inhibiting ACC activity

Similarly, KRAS mutations in tumor cells promote glutamine metabolism by inducing the expression of glutamate oxaloacetate transaminase (GOT), contributing to the maintenance of tumor cell proliferation and survival (53, 54)

Topiramate blocks the ionotropic glutamate receptors in the trigeminothalamic pathway, as well as sodium and calcium channels with GABA signal enhancement (87)

When the cream is applied regularly, it results in healthy, glowing, and silky smooth skin by deeply nourishing the creased skin layer and reviving the natural bright tone