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(2022) 80:50212.e1

AOD9604 displayed a very good safety and tolerability profile indistinguishable from placebo

There is also some evidence that metformin may be effective in improving aberrant behavior and correcting electrophysiological abnormalities in patients with fragile X syndrome, but no clinical trials have tested its effects on ovary function in these patients (Proteau-Lemieux et al., 2021)