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Maintaining sufficient glutathione stores protects hepatocytes from oxidative stress and supports efficient detoxification

2002, Fulcrand et al

Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

H 2 S is mainly generated by three endogenous enzymes with different organ/tissue distributions, all of which are related to cysteine metabolism: the trans-sulphuration pathway pyridoxal-5-phosphate-dependent-CBS and CSE, and 3-MST