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Although quercetin and metformin are found to possess antidiabetic activity in unison and their mechanism is found to be unclear, the combination therapy exhibits synergistic effects

These include enzymatic antioxidants such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, which neutralize ROS, and non-enzymatic antioxidants such as vitamin C, vitamin E, and glutathione, which scavenge free radicals [15]

Researchers found that berberine inhibited the expression of VEGF and fibronectin in breast cancer cells that were induced by TPA, and it also inhibited the synthesis of fibronectin that was driven by VEGF

Enrichment analysis of these DEGs on Gene Ontology (GO) annotations showed that, in general, T3-downregulated genes are mostly involved in oxidoreductase activity, glutathione metabolic processes and xenobiotic metabolic processes, regardless of the cell type