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(-)-Vestitol, Salviolone, and their combination showed no toxicity in the safety evaluation experiment To assess the safety of the natural products, we recorded the general behavior, mortality, and body weight of the mice

When taken orally, they face two major obstacles: Stomach acid: Hydrochloric acid (pH 1.5-3.5) denatures peptide bonds, breaking the molecule into inactive fragments before it can be absorbed Digestive enzymes: Pepsin, trypsin, and chymotrypsin in the stomach and small intestine specifically target peptide bonds for cleavage