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FSEN1 was identified as a small-molecule inhibitor of FSP1 through chemical screening 118 , and subsequent structural analyses revealed that FSEN1 occupies the substrate-binding pocket of FSP1 in a position analogous to CoQ observed in the enzyme active site, providing structural insight into inhibitor recognition 119

Functional assessments such as creatine loading tests and advanced tissue imaging (e.g., magnetic resonance spectroscopy) may offer dynamic, patient-specific evaluations of mitochondrial responsiveness and guide individualized preventive protocols

1071 Both BAT and tumor cells rely on glucose as their primary energy source

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