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AHK-Cu is applied topically to the scalp and works at the follicle cell level: stimulating dermal papilla cell proliferation, reducing TGF-beta-1 to extend anagen, upregulating VEGF for better blood supply, and reducing oxidative stress

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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 4), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification