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Free water imaging, calculated from diffusion weighted MRI, separating the diffusion properties within tissue from those in the extracellular space, can also be used as a measure of SN dopaminergic neuronal degeneration in PD, where increases in extracellular space correspond to loss of neurons 51

468 Hyperactivation of mTORC1 reduces the autophagic clearance of amyloid-beta, promoting its accumulation in the brain

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