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doi: 10.18632/aging.102454 [DOI] [PMC free article] [PubMed] [Google Scholar] 249.Estepa-Fernndez A, Garca-Fernndez A, Lrida-Viso A, et al

Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling