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Jiang, R., Diaz-Castro, B., Looger, L

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The uptake of oxidized-low density lipoprotein (oxLDL) was also decreased by butyrate treated cells ( In high-fat diet-fed ApoE / mice, butyrate administration (200 and 400 mg/kg) influenced the microbial composition of the gut and improved diversity in favor of increasing Firmicutes specially Bacteroidetes ( in vivo , ex vivo and in vitro investigations illustrated that butyrate induces ATP-binding cassette subfamily A member 1 (ABCA1) activity in both hepatocytes and macrophages via transcription factor specific protein 1 (Sp1), which causes reduced total cholesterol (TC) and also cholesterol deposition in plaque ( Inflammation and oxidative stress are well-known in the pathogenesis of atherosclerosis ( Taken together, these findings indicate that athero-protective effects of butyrate are accompanied by regulating the expression of genes related to lipid and glucose metabolism, improving gut microbiota diversity, suppressing a wide range of inflammatory and oxidative processes, rescuing protective KLF2, and enhancing vascular health