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Finally, we outline translational prospects, arguing that targeting this pathway will require precision medicine strategies, including composite biomarkers and rational combination therapies

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Involving a diverse group of participants aged 65 to 79 with or at risk for age-related diseases, the study utilizes a randomized, double-blind, placebo-controlled design to rigorously evaluate metformins geroprotective effects ( 5.1.3 Caloric restriction mimetics CR - as mentioned previously in this review, has long been associated with enhanced longevity and delayed aging across various organisms, primates and mice included (Xie et al., 2022)