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IL-4 and IL-13 suppress pro-inflammatory cytokine production by upregulating transforming growth factor beta (TGF-) activity (70)

highlighted that ferroptosis could not be explained by a simple increase in H 2 O 2 -dependent, iron-catalyzed ROS production (i.e., Fenton chemistry), as H 2 O 2 , but not erastin (which depletes cellular glutathione), induced substantial depletion of intracellular adenosine triphosphate (ATP), hinting at different toxic mechanisms [16]