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furthermore, NET inhibitors repressed NET formation and reduced M1 macrophage markers in a mouse model of acute lung injury (Song et al., 2019)

NFL, neurofilament light protein

25 Thus, high levels of aldehyde dehydrogenase in the liver, early hematopoietic cells, and intestinal stem and mucosal absorptive cells are consistent with reduced hepatic, gastrointestinal (GI), and hematopoietic toxicities associated with cyclophosphamide as compared to other alkylating agents

These data suggests that CFTR has important roles in exporting GSH and SCN which are protective against oxidants and that hypertonic saline treatment may have beneficial effects by increasing their levels in the lung