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Specifically, the catechol estrogen-3,4-quinones can react with DNA to produce a large amount of specific depurinating estrogen-DNA adducts, formed at the N-3 of Ade and N-7 of Gua

If side effects are troublesome, dose adjustments or discontinuation may be considered

INTRODUCTION Oxidative stress is a facet of many diseases, such as chronic lung diseases (for example, asthma, chronic obstructive pulmonary disease, lung cancer, idiopathic fibrosis and cystic fibrosis), cardio- vascular diseases/disorders (such as atherosclerosis and myocardi- al infarction), neurodegenerative disorders, rheumatoid arthritis, amyotrophic lateral sclerosis and diabetes, and has recently been implicated in AIDS1

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