glutathione in the treatment of chronic fatty liver diseases scholar Role natural compounds non-alcoholic (NAFLD): a mechanistic approach | Egyptian Liver Journal Changes in Glutathione Content in

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Pathological mediators like inducible nitric oxide synthase (iNOS) and hydrogen peroxide (H 2 O 2 ) impair the electron transport chain in M1 macrophages, leading to mitochondrial dysfunction and excessive accumulation of reactive oxygen species (ROS) and mitochondrial ROS (mtROS), which amplify inflammatory cascades and exacerbate oxidative stress [15,16,17]

SLE patients also have lower hematocrit levels compared to healthy individuals and exhibit a higher percentage of PS-exposing erythrocytes, elevated cytosolic Ca 2+ levels, abundance of ROS, and significant erythrocyte shrinkage [327, 328]