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Hypoxia-mediated increases in l-2-hydroxyglutarate coordinate the metabolic response to reductive stress

An increase in intracellular ROS is a major signal that reacts with intracellular iron to produce more active ROS-type hydroxyl radicals (HO) that trigger ferroptosis [81]

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Wert K.J., Velez G., Cross M.R., Wagner B.A., Teoh-Fitzgerald M.L., Buettner G.R., McAnany J.J., Olivier A., Tsang S.H., Harper M.M., et al