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In hypoxic conditions, HIF-1 acts as the main mediator of a series of in vivo pathophysiological responses, including angiogenesis, cell proliferation, and transcriptional induction of survival genes (30)

Video above: Olympic skiers Alex Hall and Colby Stevenson blend filmmaking with competition The easy availability of the drugs combined with their hard-to-detect nature is precisely the toxic combination doping regulators and Olympic officials are trying to avoid

Moreover, an autocrine loop of MET activation has been reported in several chemoresistant cancer cell lines, leading to their increased viability [2, 28, 37]

Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo