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Results: Transient increases 3 to 31-fold from baseline in immune biomarkers associated with immune activation (sCD40, sCD28, sCD80, sCD86), Th1 cell-mediated response (IL-6, IL-12 p40, IL-12 p70, IL-7, IL-10), inflammation regulation (GROa, PDGF-AA, PDGF-AB, VEGF), and immune checkpoint proteins (PD-1, PD-L1, CTLA-4, LAG-3, BTLA) were observed during IDR lead-in, with peaks occurring during the plateau of HBsAg reduction in assessed subjects to date

Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-B pathway and secrete chemokines