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Hyperpolarized [1-13C]pyruvate MRI can assess the balance between aerobic glycolysis (pyruvate-to-lactate conversion) and OXPHOS (pyruvate-to-TCA cycle flux), providing functional information about metabolic phenotypes

397 TTM also exhibits radiosensitizing and chemosensitizing effects, 398,399 enhancing the efficacy of chemotherapeutic agents like doxorubicin, mitomycin C, fenretinide, 5-fluorouracil, and cisplatin in preclinical models without increasing side effects

Hormonal changes during pregnancy or from oral contraceptives can also trigger hyperpigmentation on the lips, closely related to the melasma that affects the face

The surgical sites require gentle treatment to ensure that blood clots remain intact, as these clots are vital for protecting the exposed bone and nerve endings while aiding the healing process