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But the detoxification process isnt complete

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Citrate will follow the citric acid cycle, but it may also exit mitochondria and allosterically inhibit phosphofructokinase-1, the step with the highest flux-control coefficient in the glycolytic pathway

Principal Investigator on A Randomized, Double-blind, Multicentre, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy. Principal Investigator on A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNR. (Janssen)