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Table 17: Exploratory Efficacy Analyses by Histologic Subgroup in Study JMEI The efficacy of pemetrexed was evaluated in Study JMCH (NCT00005636), a multicenter, randomized (1:1), single-blind study conducted in patients with MPM who had received no prior chemotherapy

Regarding the results of all of these studies, they found a dose-response relationship between serum homocysteine and the odds ratio of ischemic heart disease, supporting the idea that homocysteine is a causal risk factor for cardiovascular disease

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