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However, creating personalized vaccines with neoantigens unique to each patient is a costly, time-consuming, and technically challenging process

J.BickebllerH.RosenbergerA.McCormackV.et al (2012)

This makes the control group as susceptible for side effects as the main group just as the case with the fraudulent approval of the HPV-vaccine Gardasil where the control group also received all the ingredients just not the antigens

Antonoff MB , Simon GR, Gold KA, Patel S, Gomez D, Ferrarotto R, Allen J, Stevens R, Suarez Saiz FJ, Berger M, Walsh G, Mynhier M, High R, Futreal A, Hahn S, Swisher S, Heymach J, Chin L