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In the Phase I/II trial, 27% of patients with indolent lymphoma achieved objective clinical responses at distant, noninjected tumor sites following intratumoral injection of the TLR9 agonist PF-3512676 combined with low-dose radiotherapy, including one complete and three partial responses

(2014) argue that autophagy inhibition can be employed independently of TP53 status, reducing the oxygen consumption rate and clonogenicity (Yang et al., 2011, 2014

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