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The structure drawing tools themselves are scripts written in the Perl [31] programming language which can generate a large number of structures relatively quickly via command-line or web-based interface

Third, due to the significant heterogeneity among tumor cells and immune cells in the TME, as well as the multidirectional and pleiotropic effects of cytokines and growth factors, it is difficult to determine the roles played by individual immune cell subsets in the overall tumor progression process

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