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Nasoni et al

The DCCT reported a 60% reduction in neuropathy in the intensively treated groups after five years and therefore, poor glycaemic control represents the most important risk factor for Dn, even in children and adolescents.2 Recently, Tesfaye et al hypothesized that other risk factors besides hyperglycaemia are probably involved in the evolution of neuropathy and, in particular, provided convincing evidence that even slight improvements in lipid variables, blood pressure and body mass index are associated with a significantly lower risk of onset of Dn

For example, mitochondria, which are the energy producers inside each cell, require nutrients in order to make energy, but if toxins get in or nutrients dont get into the cell due to unhealthy cell walls, then mitochondria cant do their job

There are changes in the water availability (Water Table dropped)