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Moreover, both extracellular and intracellular a-synuclein oligomers can form Ca 2+ -permeable pores to elevate intracellular Ca 2+ concentration and cell death [6, 7]

Notably, XKR8 KO BMNs failed to generate both filamentous chromatin structures and the citrullinated histones, suggesting a disruption in upstream NET signaling, particularly in Ca 2+ signaling pathways, given that peptidylarginine deiminase 4 (PAD4) activation is calcium-dependent 34

Cultured human RPE cells are susceptible to apoptotic cell death induced by Ultraviolet B (UVB) irradiation

According to the Centers for Disease Control and Prevention (CDC), healthcare providers frequently prescribe acetaminophen instead of opioids for mild to moderate pain management, as it does not produce euphoria or cause dependence