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In oxaliplatin-induced CIPN models, melatonin prevented the loss of mitochondrial membrane potential (m), promoted nerve regeneration in oxaliplatin-challenged Neuro-2a cells and prevented the loss of nitrosation of proteins and antioxidant enzymes by improving nitrooxidative stress mediated by the chemotherapeutic agent oxaliplatin [45] without interfering with oxaliplatin cytotoxic activity in human colon cancer cell lines

Perez de la Lastra JM, Plou FJ, Perez-Lebena E: The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

M., Taya, Y

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